Fig. 3 | Scientific Reports

Fig. 3

From: Involvement of LncRNA FAF in chemotherapy-induced cardiotoxicity by mediating pyroptosis through modulation of the NLRP3-Caspase-1 signaling pathway

Fig. 3

lncRNA FAF is lowly expressed in a model of chemotherapy-induced cardiomyocyte injury. (A) Identification of cardiomyocytes via immunofluorescence assay targeting cTnT; (B) Evaluation of DOX’s effect on the viability of rat cardiomyocytes via CCK-8 assay; (C-D) Representative flow cytometric speckled plots and quantification of pyroptotic cells; (E) Supernatant IL-18 levels (ELISA); (F) Supernatant IL-1β levels (ELISA); (G) WB electropherograms of NLRP3, C-Caspase1, and GSDMD-N; (H) qRT- PCR detection of lncRNA FAF expression. N = 3.

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