Table 3 Pharmacokinetic parameters of ganciclovir in new Zealand white rabbits following oral administration of valganciclovir hydrochloride (5 mg/kg).

From: Validated Erythrosin B spectrofluorimetric method for ganciclovir bioanalysis in rabbit plasma following valganciclovir bioconversion and Pharmacokinetic application

Pharmacokinetic Parameter

Value

CV (%)

Absorption

  

Cmax (µg/mL)

4.25 ± 0.77

18.1

Tmax (h)ᵃ

2.0 (1.5–2.5)

19.9

Distribution

  

Vz/F (L)

0.99 ± 0.13

12.9

Elimination

  

t½ (h)

2.94 ± 0.32

11.0

CL/F (L/h)

0.24 ± 0.03

13.2

Exposure

  

AUC0→ t (µg·h/mL)

21.1 ± 2.6

12.3

AUC0→ ∞ (µg·h/mL)

21.6 ± 2.7

12.6

MRT (h)

4.52 ± 0.71

15.6

  1. ᵃ Median (range)
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