Table 4 Comparison between COPD patients with and without albuminuria according to physiological data.

From: Albuminuria as a non-invasive biomarker of endothelial dysfunction in patients with COPD

 

Total (n = 60)

Patients with albuminuria (n = 16)

Patients without albuminuria (n = 44)

P

Post-BD FEV1 (%pred)

59.9 ± 20.7a

58.6 ± 20.9a

60.3 ± 21a

0.802

Post-BD FVC (%pred)

79.4 ± 19.8a

75.9 ± 17.5a

80.6 ± 20.6a

0.489

Post-BD FEV1/FVC

59.6 (54.2–65.1)b

59.5 (54.2–63.8)b

62.9 (52.3–65.3)b

0.617

Bronchodilator response (% change in FEV1)

6 (0–17)b

5.6 (0.4–17.3)b

9.6 (0–17)b

0.980

Post-BD PEF (%pred)

50.8 ± 22.3a

50.5 ± 22.6a

51.4 ± 22.4a

0.916

Post-BD FEF75% (%pred)

29.5 ± 15.6a

28.5 ± 12.8a

32.3 ± 22.2a

0.587

Post-BD FEF25−75%

31.4 ± 17.9a

30.5 ± 15.7a

34 ± 23.6a

0.567

HR (beat/min)

74.5 ± 10.1a

79 ± 10.7a

72.9 ± 9.6a

0.075

Systolic ABP (mm Hg)

120 ± 14.3a

123.3 ± 15.1a

118.8 ± 14.1a

0.288

Diastolic ABP (mm Hg)

80.2 ± 9.1a

82.3 ± 9.1a

79.4 ± 9.2a

0.283

SpO2%

94.70 ± 2.60a

91.25 ± 1.86a

95.91 ± 1.48a

< 0.001*

6MWD (m)

138.5 (120–190)b

138.5 (120–190)b

142 (128.5–181.5)b

0.802

BODE Index

4.9 ± 2.5a

4.5 ± 2a

5 ± 2.7a

0.563

FMD (% change in brachial artery diameter)

4.13 ± 1.23a

3.35 ± 0.94a

4.52 ± 1.38a

0.003*

  1. a; mean ± standard deviation, b; median (interquartile range), p: p-value for comparing COPD patients with albuminuria and patients without albuminuria, post-BD: post-bronchodilator value, FEV1: forced expiratory volume in the first second, %pred: percent of predicted value, FVC: forced vital capacity, PEF: peak expiratory flow, FEF50%: forced expiratory flow at 50% of the FVC, FEF75%: forced expiratory flow at 75% of the FVC, FEF25−75%: forced expiratory flow at 25–75% of the FVC, HR: heart rate, RR: respiratory rate, ABP: arterial blood pressure, SpO2; peripheral oxygen saturation, 6MWD: six-minute walk distance, BODE index: (Body mass index, airflow Obstruction, Dyspnea, and Exercise capacity) index, FMD: flow-mediated dilation.
  2. *: Statistically significant at p ≤ 0.05.