Table 3 Changes in biochemistry tests before and after the study in CR and IF groups.

From: Comparative effects of intermittent fasting and calorie restriction on cardiovascular health in adults with overweight or obesity

Variables

Group

Baseline

Week 12

Change

P-value

P-value c

Triglyceride (mg/dL)

IF

CR

145.59 ± 56.21

113.38 ± 40.90

124.96 ± 50.18

105.07 ± 44.14

−20.63 ± 49.67

−8.31 ± 36.36

0.04 a

0.11 a

0.63

Cholesterol (mg/dL)

IF

CR

180.17 ± 38.41

179.86 ± 31.11

171.57 ± 44.48

175.62 ± 40.89

−8.60 ± 25.82

−4.24 ± 21.54

0.08 a

0.30 a

0.59

LDL-C (mg/dL)

IF

CR

100.08 ± 31.22

112.30 ± 26.26

98.66 ± 27.95

107.03 ± 31.77

−1.42 ± 27.04

−5.27 ± 19.47

0.74 a

0.51 a

0.84

HDL-C (mg/dL)

IF

CR

42.14 ± 7.53

42.90 ± 8.95

41.73 ± 6.75

43.67 ± 10.63

−0.41 ± 7.01

0.77 ± 6.33

0.78 a

0.15 a

0.42

FPG (mg/dL)

IF

CR

93.92 ± 13.17

94.57 ± 12.34

89.33 ± 1.85

90.97 ± 11.83

−4.59 ± 13.51

−3.60 ± 10.10

0.06 a

0.06 a

0.67

HbA1c (%)

IF

CR

5.39 ± 0.72

5.42 ± 0.86

5.08 ± 0.40

5.34 ± 0.18

−0.31 ± 0.72

−0.08 ± 0.44

0.06 a

0.48 a

0.15

ALT (IU/L)

IF

CR

31.85 ± 24.11

27.21 ± 19.93

25.07 ± 15.86

23.77 ± 14.31

−8.13 ± 12.29

−3.17 ± 17.80

< 0.001 b

0.31 b

0.44

AST (IU/L)

IF

CR

26.18 ± 9.99

24.92 ± 11.63

21.49 ± 8.68

23.08 ± 9.09

−4.70 ± 7.89

−1.84 ± 8.33

< 0.001 a

0.28 a

0.23

Urea (mmol/L)

IF

CR

26.85 ± 4.38

25.67 ± 7.07

27.92 ± 8.60

22.78 ± 6.65

1.08 ± 6.76

−2.89 ± 4.96

0.58 a

0.12 a

0.34

Creatinine (mg/dL)

IF

CR

0.94 ± 0.18

0.90 ± 0.13

0.95 ± 0.17

0.87 ± 0.11

0.01 ± 0.17

−0.03 ± 0.17

0.66 a

0.48 a

0.13

Uric acid (mg/dL)

IF

CR

5.20 ± 1.32

5.21 ± 1.74

4.94 ± 1.32

4.76 ± 1.69

−0.26 ± 1.16

−0.45 ± 1.22

0.27 a

0.15 a

0.26

TSH (µU/mL)

IF

CR

3.53 ± 2.72

3.80 ± 3.39

3.62 ± 6.40

4.50 ± 6.48

0.26 ± 7.40

0.60 ± 6.54

0.28 b

0.79 b

0.65

  1. a Paired sample T-test, b Wilcoxon signed rank test, c Analysis of Covariance (ANCOVA), adjusted for baseline values of each variable, age, sex and BMI. Abbreviations: IF: intermittent fasting; CR: calorie restriction; LDL-C: low density lipoprotein-cholesterol; HDL-C: high density lipoprotein-cholesterol; FPG: fasting plasma glucose; HbA1c: hemoglobin A1c; ALT: alanine transaminase; AST: aspartate aminotransferase; TSH: thyroid stimulating hormone.