Fig. 5 | Scientific Reports

Fig. 5

From: Novel fully human IgG1 targeting folate receptor α demonstrates antitumor efficacy driven by avidity rather than monovalent binding affinity

Fig. 5

Antibody-dependent cytotoxicity. Percentage of cell growth inhibition is reported in the presence of: PBMCs alone (green lines), AFRA hIgG1 alone (light blue lines), ChiMOv19 alone (orange lines) or AFRA hIgG1 (blue lines) and ChiMOv19 (red lines) with the addition of PBMC at E: T ratio of 10:1 from 24 to 120 h on FRα positive (IGROV1; Panel a) and FRα negative (A431; Panel b) cell lines. Antibodies’ concentration used was 2 µg/ml. Statistical analysis: IGROV1: AFRA hIgG1 + PBMC vs. PBMC p < 0.0001; IGROV1: ChiMOv19 + PBMC vs. PBMC p < 0.0001.

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