Table 1 Results of the digital pathology evaluation. The mean value is ± standard deviation.

From: Multimodal objective assessment of a porcine limbal stem cell deficiency model for corneal therapy research

Parameter

Study group

Control group

p value

Number of samples (n)

4

4

 

Corneal thickness

Number of measurements (total)

718

812

 

Number of measurements per eye (avg)

179.50 ± 18.52

203.00 ± 24.29

0.17480‡

Epithelium thickness (avg total)

80.47 ± 18.39

77.36 ± 11.49

0.00010†

Epithelium thickness (avg of avgs)

80.20 ± 6.59

77.67 ± 4.27

0.57160‡

Minimal epithelium thickness (avg)

37.51 ± 13.11

49.02 ± 2.83

0.21180‡

Maximum epithelium thickness (avg)

126.67 ± 21.50

95.67 ± 3.51

0.15430‡

Max-min difference (avg)

78.11 ± 47.37

63.00 ± 33.51

0.50570‡

Arithmetic Mean Roughness (Ra)

0.83 ± 0.19

0.68 ± 0.21

0.18160‡

Maximum Height of Profile (Rz)

4.39 ± 1.32

2.88 ± 0.73

0.04940‡

Corneal thickness distribution

Measurements exceeding 1 σ

12.53% ± 10.82

13.18% ± 18.46

0.86530‡

Measurements exceeding 2 σ

3.90% ± 2.57

1.60% ± 3.74

0.08000‡

Measurements exceeding 3 σ

1.25% ± 1.45

0.25% ± 0.57

0.23020‡

Skewness

0.73 ± 0.98

-0.43 ± 0.46

0.08550‡

Rolling Standard Deviation

8.64 ± 2.63

4.36 ± 1.25

0.06860‡

Epithelium cells density

Analyzed Area (total) – mm2

18.99

9.19

 

Analyzed Area Mean Per eye (avg) – mm2

2.54 ± 3.05

1.15 ± 0.08

0.4990‡

Cell density (total) – cells/mm2

2205.0

6394.0

 

Cell density (avg) – cells/mm2

4271.0 ± 2184.0

6390.0 ± 762.0

0.1683‡

Stroma cells density

Analyzed Area (total) – mm2

45.84

48.52 ±

 

Analyzed Area Mean Per eye (avg) – mm2

5.73 ± 0.78

6.07 1.38

0.6330‡

Cell density (total) – cells/mm2

1272.0

548.0

 

Cell density (avg) – cells/mm2

2534.0 ± 662.1

1082.0 ± 224.0

0.0179‡

  1. † – unpaired T Test, ‡ – paired T Test. Significance are in bold.
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