Table 1 Minimum inhibitory concentrations (MICs) of representative antipseudomonal antibiotics, BZs and the solvent used, determined in PAO1 strain.

From: Analyzing the effects of benzodiazepines on the virulence and biofilm formation of Pseudomonas aeruginosa

Conditionsa

MICsb

SOL

DIA

MID

CAZ

FEP

TOL

PIP

AZT

IMP

MER

CIP

GEN

COL

CONTROL

12.5

250

250

1

1

0.5

2

2

1

0.5

0.12

1

0.5

SOL 0.5%

-

-

-

1

1

0.5

4

2

2

1

0.12

1

0.5

DIA 10 µg/ml

-

-

-

1

1

0.5

4

2

1

1

0.12

1

0.5

MID 10 µg/ml

-

-

-

1

1

0.5

2

2

2

1

0.12

1

0.5

  1. aMICs were determined in regular Mueller-Hinton broth (control), or supplemented with each additive displayed on the left column at the concentration shown. bMIC of solvent is expressed in percentage (vol./vol.), whereas those of BZs and antibiotics are in µg/ml. Abbreviations: SOL: solvent (40% propylene glycol, 10% alcohol, 4.9% sodium benzoate and 0.1% benzoic acid); DIA: diazepam; MID: midazolam; CAZ: ceftazidime; FEP: cefepime; TOL: ceftolozane; PIP: piperacillin; AZT: aztreonam; IMP: imipenem; MER: meropenem; CIP: ciprofloxacin; GEN: gentamicin; COL: colistin.
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