Table 2 H. pylori detection concordance with gastric mucosa reference.

From: Comparative molecular profiling of Helicobacter pylori infection and antibiotic genotypic resistance in paired gastric mucosa, gastric juice, and stool samples

Parameter

Stool

Gastric juice

Positive rate

197 (90.4%)

208 (95.4%)

Sensitivity (%, 95% CI)

91.3 (86.8–94.6)

97.6 (94.6–99.1)†

Specificity (%, 95% CI)

30.0 (10.8–60.3)

50.0 (23.7–76.3)

Kappa (95% CI)

0.025 (0–0.089.089)

0.476 (0.211–0.741)‡

AUC (95% CI)

0.606 (0.532–0.680)

0.738 (0.675–0.801)§

True positive (n)

190

203

True negative (n)

3

5

False positive (n)

7

5

False negative (n)

18

5

PPV (%, 95% CI)

96.4 (92.8–98.3)

97.6 (94.6–99.1)

NPV (%, 95% CI)

14.3 (4.8–33.4)

50.0 (23.7–76.3)

Accuracy (%, 95% CI)

88.5 (83.5–92.3)

95.0 (91.1–97.2)

  1. †McNemar’s test for sensitivity comparison: P = 0.003. ‡Kappa comparison (z-test): z = 3.12, P = 0.002. §DeLong’s test for AUC comparison: P < 0.001.
  2. Cohen’s Kappa values representing levels of agreement are categorized as follows: > 0.90, almost perfect; 0.80 to 0.90, strong; 0.60 to 0.79, moderate; 0.40 to 0.59, weak; 0.21 to 0.39, minimal; 0 to 0.20, none.
  3. Abbreviations: CI, confidence intervals; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the ROC curve.
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