Fig. 6
From: Limited therapeutic efficacy of N-acetyl-L-leucine in a mouse model of CLN1 disease
NALL does not attenuate glial activation or storage burden in thalamocortical regions of Ppt1−/− mice. (A) Representative images of SCMAS, CD68 and GFAP staining. (B) Quantification of CD68, GFAP, and SCMAS immunoreactivity in the primary somatosensory cortex (S1BF) and ventral thalamic nuclei (VPM/VPL) of PPT1-deficient (Ppt1−/−) and wild type (WT) mice at 7 months of age. Data represent mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; ns = not significant (two-way ANOVA with Bonferroni post hoc test). Scale bar = 200 μm.
