Table 2 Percentage of flagged antibodies for each therapeutic antibody profiling (TAP) metric.
Descriptor | Acceptable region | Percentage of flagged antibodies for each metric [Number of antibodies provided in brackets] | |||
|---|---|---|---|---|---|
Target A paired [70] | Target A combinatorial [23] | Target B paired [84] | Target B combinatorial [21] | ||
Patches of surface hydrophobicity (PSH) | 82.8 < x < 127.8 | 5.7% [4] | 8.7% [2] | 9.5% [8] | 0% [0] |
Patches of positive charge (PPC) | x < 1.29 | 0% [0] | 0% [0] | 0% [0] | 4.8% [1] |
Patches of negative charge (PNC) | x < 1.98 | 4.2% [3] | 8.7% [2] | 0% [0] | 4.8% [1] |
Structural Fv charge symmetry parameter (SFvCSP) | x > − 6 | 2.9% [1] | 4.3% [1] | 0% [0] | 4.8% [1] |
CDR length | x < 60 | 0% [0] | 0% [0] | 0% [0] | 0% |
Total unique, flagged antibodies | 12.8% [9] | 21.7% [5] | 9.5% [8] | 14.3% [3] | |
