Table 1 Descriptives of GMS groups at timepoint 1.

Age (years)

58.00 [52.00, 63.00]^{b, c,d, e,f}

63.00 [59.00, 68.00]^a

63.00 [57.00, 67.00]^a

62.00 [56.00, 66.00]^a

60.29 (6.88)^a

60.06 (7.78)^a

Female (%)

580 ( 59.5)^{c, f}

45 ( 50.6)^c

67 ( 23.8)^{a, b,d, e,f}

90 ( 54.2)^c

50 ( 45.0)^c

43 ( 42.6)^{a, c}

Educational level (%)

 Low

231 ( 24.1)

23 ( 26.1)

92 ( 33.5)

41 ( 24.8)

34 ( 30.6)

27 ( 27.0)

 Mid

273 ( 28.4)

31 ( 35.2)

83 ( 30.2)

51 ( 30.9)

28 ( 25.2)

27 ( 27.0)

 High

456 ( 47.5)

34 ( 38.6)

100 ( 36.4)

73 ( 44.2)

49 ( 44.1)

46 ( 46.0)

 Missing

15

1

7

1

1

Smoking status (%)

 Never (1)

420 ( 43.3)^c

24 ( 27.3)

88 ( 31.9)^a

77 ( 46.7)

47 ( 42.3)

32 ( 32.0)

 Former (2)

468 ( 48.3)^c

59 ( 67.0)

157 ( 56.9)^a

75 ( 45.5)

53 ( 47.7)

63 ( 63.0)

 Current (3)

81 ( 8.4)^c

5 ( 5.7)

31 ( 11.2)^a

13 ( 7.9)

11 ( 9.9)

5 ( 5.0)

 Missing

6

1

3

1

1

Alcohol (%)

 None (1)

123 ( 12.7)

12 ( 13.6)

50 ( 18.1)

20 ( 12.1)

17 ( 15.3)

13 ( 13.0)

 Low (women:≤7; men:≤14) (2)

590 ( 61.0)

50 ( 56.8)

163 ( 59.1)

91 ( 55.2)

55 ( 49.5)

55 ( 55.0)

 High women > 7; men > 14) (3)

255 ( 26.3)

26 ( 29.5)

63 ( 22.8)

54 ( 32.7)

39 ( 35.1)

32 ( 32.0)

 Missing

7

1

6

1

1

DHD15

85.60 [75.95, 96.65]^c

84.25 [71.58, 93.20]

82.20 [70.70, 90.42]^a

86.88 [76.37, 95.01]

80.70 [68.79, 93.16]

83.94 [74.82, 94.18]

 Missing

19

6

4

4

1

BMI (kg/m²)

24.70 [22.80, 26.80]^{b, c,d, e,f}

26.80 [24.70, 29.50]^{a, c}

28.70 [25.90, 31.48]^{a, b,d, f}

26.37 (3.21)^{a, c}

27.40 [25.15, 30.05]a

26.00 [23.90, 28.50]^{a, c}

WC (cm)

88.20 [80.45, 95.40]^{b, c,d, e,f}

96.25 (11.36)^{a, c}

104.55 [95.32, 112.22]^{a, b,d, e,f}

93.41 (10.11)^{a, c,e}

98.63 (11.73)^{a, c,d}

93.40 [86.00, 101.50]^{a, c}

WHR

0.89 [0.83, 0.96]^{b, c,d, e,f}

0.94 (0.08)^{a, c}

1.02 [0.96, 1.07]^{a, b,d, e,f}

0.93 (0.08)^{a, c,e}

0.96 (0.08)^{a, c,d}

0.93 (0.09)^{a, c}

 Missing

4

2

1

Systolic blood pressure (mmHg)

128.00 [117.00, 140.00]^{b, c,d, e,f}

138.02 (17.87)^a

141.26 (17.15)^{a, d,f}

134.20 (17.56)^{a, c}

139.23 (17.00)^a

133.90 (15.85)^{a, c}

Diastolic blood pressure (mmHg)

74.00 [68.00, 80.00]^{c, e}

76.90 (8.75)^e

77.02 (9.70)^a

76.05 (10.69)^e

79.75 (9.95)^{a, d}

76.28 (8.73)

HDL-cholesterol (mmol/L)

1.70 [1.40, 2.00]^{b, c,e, f}

1.50 [1.20, 1.70]^{a, c}

1.20 [1.00, 1.40]^{a, b,d, e,f}

1.60 [1.30, 1.90]^{c, e,f}

1.40 [1.20, 1.65]^{a, c,d, e,f}

1.50 [1.20, 1.8]^{a, c,e}

LDL-cholesterol (mmol/L)

3.30 [2.70, 3.90]c

3.39 (0.99)c

2.30 [1.80, 2.90]^{a, b,d, e,f}

3.37 (0.92)^c

3.26 (1.05)^c

3.00 [2.50, 3.6]^c

Triglycerides (mmol/L)

1.03 [0.78, 1.37]^{b, c,d, e,f}

1.41 [0.99, 2.01]^a

1.51 [1.13, 2.31]^{a, d}

1.23 [0.90, 1.62]^{a, c,e}

1.53 [1.06, 1.96]^{a, d}

1.31 [1.03, 1.76]^a

Fasting glucose (mmol/L)

5.10 [4.80, 5.40]^{b, c,d, e,f}

5.90 [5.40, 6.20]^{a, c,d}

7.40 [6.80, 8.38]^{a, b,d, e,f}

5.40 [5.10, 5.70]^{a, b,c, e,f}

5.90 [5.50, 6.20]^{a, c,d}

5.60 [5.30,6.1]^{a, c,d}

2 h-glucose (mmol/L)

5.10 [4.30, 5.80]^{b, c,d, e,f}

8.23 (1.42)^{a, c,d}

14.53 (3.56)^{a, b,d, e,f}

6.00 [5.00, 6.90]^{a, b,c, e,f}

7.74 (1.83)^{a, c,d}

8.40 [7.80, 8.9]^{a, c,d}

 Missing

7

52

1

1

HbA1c (mmol/mol)

35.00 [32.00, 37.00]^{b, c,d, e,f}

37.58 (3.37)^{a, c}

49.00 [45.00, 54.00]^{a, b,d, e,f}

36.81 (3.24)^{a, c}

39.00 [36.00, 42.00]^{a, c}

36.57 (4.40)^{a, c}

 Missing

1

1

Duration T2DM (years)

NaN (NA)

NaN (NA)

4.00 [1.00, 9.00]

NaN (NA)

NaN (NA)

NaN (NA)

Glucose lowering mediation = yes (%)

0 (0.0)^c

0 (0.0)^c

215 (76.2)^{a, b,d, e,f}

0 (0.0)^c

0 (0.0)^c

5 (5.0)^{a, b,c, d,e}

Blood pressure lowering medication = yes (%)

177 (18.2)^{b, c,e, f}

30 (33.7)^{a, c}

187 (66.3)^{a, b,d, f}

47 (28.3)^{c, e}

59 (53.2)a, d

45 (44.6)^{a, c}

Lipid lowering medication = yes (%)

116 (11.9)^{b, c,d, e,f}

29 (32.6)^{a, c}

204 (72.3)^{a, b,d, e,f}

40 (24.1)^{a, c}

45 (40.5)^{a, c}

31 (30.7)^{a, c}

Current depression (MINI) = yes (1) (%)

20 (2.1)

1 (1.2)

8 (3.0)

3 (1.8)

3 (2.8)

6 (6.2)

 Missing

32

6

12

3

2

4

PHQ9

2.00 [0.00, 4.00]

1.00 [0.00, 3.00]

1.00 [0.00, 3.00]

2.00 [0.00, 3.00]

1.00 [0.00, 4.00]

2.00 [0.00, 4.00]

 Missing

38

4

19

7

3

4

SF36 PCS

54.09 [49.37, 56.63]^c

53.52 [50.27, 55.69]

52.01 [47.35, 54.91]^{a, d,f}

53.33 [49.55, 56.48]^c

53.57 [49.32, 55.92]

53.93 [48.52, 56.68]^c

 Missing

11

1

10

1

1

SF36 MCS

55.59 [51.14, 58.44]^c

55.11 [51.08, 58.40]

56.79 [53.06, 59.08]^a

56.09 [53.53, 58.58]

55.94 [52.19, 58.86]

56.23 [51.72, 58.30]

 Missing

11

1

10

1

1