Table 3 Multivariable Cox regression analysis for mortality.

Outcome	Model I		Model II		Model III
Outcome	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
28-day mortality
Original cohort	0.62 (0.42–0.90)	0.022	0.59 (0.40–0.86)	0.006	0.62 (0.41–0.95)	0.027
Matched cohort	0.61 (0.37–0.99)	0.044	0.58 (0.35–0.94)	0.026	0.55 (0.31–0.95)	0.031
180-day mortality
Original cohort	0.64 (0.48–0.85)	0.002	0.61 (0.46–0.82)	< 0.001	0.65 (0.48–0.90)	0.008
Matched cohort	0.62 (0.44–0.89)	0.009	0.59 (0.42–0.84)	0.004	0.56 (0.38–0.85)	0.006
In-hospital mortality
Original cohort	0.60 (0.41–0.88)	0.009	0.57 (0.39–0.83)	0.004	0.60 (0.39–0.92)	0.018
Matched cohort	0.59 (0.36–0.96)	0.034	0.55 (0.34–0.90)	0.018	0.54 (0.30–0.96)	0.036

Model I: crude.
Model II: adjusted for age, gender, ethnicity, weight.
Model III: adjusted for model II, covariates, ventilation, CRRT, vasopressin, malignancy, renal failure, heart failure, platelets, WBC, RBC, AG, BUN, creatinine, INR, MAP, respirator rate, temperature, SOFA, SAPS II, CCI.

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