Fig. 6 | Scientific Reports

Fig. 6

From: Polyacrylic acid, but not polyethylene glycol, induces metabolic reprogramming linked to pulmonary fibrosis in rats

Fig. 6

Sankey diagram representation of metabolite–pathway–phenotype relationships across two comparisons. (A) A45 vs. control (21 significantly altered metabolites; 20 upregulated, 1 downregulated). (B) PEG vs. control (5 significantly altered metabolites; 4 upregulated, 1 downregulated). Differential metabolites (FDR < 0.05) were mapped to KEGG pathways and grouped into higher-level phenotype categories. Link widths vary visually depending on layout, but do not encode quantitative information. Metabolites on the left axis are ordered by decreasing |log₂FC| (top = larger |log₂FC|), with red indicating upregulation and blue indicating downregulation.

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