Fig. 2

MIE models associated with OECD TGs. OECD TG 414, yellow; OECD TG 416, blue; OECD TG 421, purple; OECD TG 422, light green; OECD TG 443, green. Agonists are shown in red, antagonists in blue, and others (inducer or activator) in black. In OECD TG 421, PR, as indicated in the boxed area, showed an association opposite to that of the other MIEs.