Table 2 Association of Tox21 assay results with OECD TG 416 data.

From: Comparative analysis of OECD guideline data and Tox21 assays to improve reproductive and developmental toxicity prediction

Tox21 assays

Fisher’s exact test

Positive

Negative

Non-directional

ARE_ago_normalized_40

0.02028

0.99086

0.03395

CAR_ant_normalized_40

0.01546

0.99501

0.02205

ERfull_ant_normalized_1

0.04092

0.98193

0.06109

ERR_ago_normalized_40

0.01022

0.99755

0.01233

FXR_ant_normalized_40

0.03052

0.98657

0.04817

HDAC_ant_normalized_1

0.00446

0.99902

0.00594

HDAC_ant_normalized_40

0.04022

0.98994

0.05255

PPARg_ago_normalized_40

0.01773

0.99337

0.02687

PR_ant_normalized_40

0.02404

0.99054

0.03107

Shh_ant_normalized_40

0.03041

0.98538

0.05676

  1. ant, antagonist; ago, agonist; normalized_1 or _40, cutoff level.
  2. Positive and negative associations correspond to right- and left-tailed Fisher’s exact tests, respectively. Non-directional refers to the two-tailed test.
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