Table 3 Association of Tox21 assay results with OECD TG 421 data.

From: Comparative analysis of OECD guideline data and Tox21 assays to improve reproductive and developmental toxicity prediction

Tox21 assays

Fisher’s exact test

Positive

Negative

Non-directional

ARfulls_ant_normalized_40

0.987514

0.023927

0.046225

ARlbd_ago_normalized_1

0.999932

0.000222

0.000379

ARlbd_ant_normalized_40

0.997344

0.006539

0.013455

Arom_ant_normalized_40

0.997664

0.004858

0.007547

CaspC_ind_normalized_1

0.997749

0.005189

0.010597

CaspC_ind_normalized_40

0.996336

0.007303

0.014853

ERb_ago_normalized_1

0.995429

0.011731

0.024333

ERfull_ant_normalized_40

0.99333

0.013022

0.023710

ERfulls_ant_normalized_40

0.999717

0.000711

0.001241

ERRPGC_ant_normalized_40

0.999748

0.000717

0.001220

ERsr_ago_normalized_1

0.995815

0.008593

0.016008

FXR_ago_normalized_40

0.998793

0.002963

0.004875

FXR_ant_normalized_40

0.999820

0.000458

0.000903

HIF1_ago_normalized_1

0.999824

0.000455

0.000835

p53_ago_normalized_40

0.993461

0.014591

0.028355

PPARd_ago_normalized_1

0.999607

0.000936

0.001542

PPARd_ant_normalized_1

0.993507

0.012359

0.020873

PPARg_ago_normalized_1

0.996763

0.006903

0.014337

PPARg_ant_normalized_40

0.998795

0.003079

0.005422

PR_ago_normalized_1

0.004707

0.995108

0.047068

RAR_ant_normalized_40

0.993142

0.013561

0.022016

ROR_ant_normalized_40

0.999854

0.000386

0.000766

Shh_ant_normalized_40

0.985468

0.026495

0.043732

TGFb_ago_normalized_1

0.999732

0.000955

0.001774

TGFb_ago_normalized_40

0.999940

0.000371

0.000621

TRHR_ago_normalized_40

0.987702

0.023199

0.038891

TSHR_agoant_normalized_40

0.998462

0.004063

0.008372

TSHR_ant_normalized_40

0.998160

0.003828

0.005922

VDR_ago_normalized_1

0.999905

0.000245

0.000459

VDR_ant_normalized_40

0.999932

0.00017

0.000256

  1. ant, antagonist; ago, agonist; normalized_1 or _40, cutoff level.
  2. Positive and negative associations correspond to right- and left-tailed Fisher’s exact tests, respectively. Non-directional refers to the two-tailed test.
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