Table 1 Properties of Doxycycline and tetracycline6,7,8,9.

From: Rhodamine B-assisted fluorescent aptasensor for the sensitive and selective assessment of Doxycycline hyclate in wastewater

Antibiotic

Doxycycline

Tetracycline

Molecular formula

C22H24N2O8

C22H24N2O8

Molecular mass

444.4

444.4

R1 R2

H OH

OH H

Water solubility

630

231

Log Kw

− 0.02

− 1.25

pKa

pKa1 3.0

pKa2 7.9

pKa3 9.2

pKa1 3.3

pKa2 7.7

pKa3 9.7

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