Table 2 Association of clinicopathological characteristics of colon cancer patients with 5-year DFS since surgical treatment.
From: Hematological markers as prognostic predictors in patients undergoing colon cancer surgery
Variable | Category | Total (n = 805) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|---|
OR (95% CI) | p value | OR (95% CI) | p value | ||||
Sex | male female | 466 339 | 1.00 0.99 (0.71–1.37) | 0.942 | |||
Age | 68.6 (± 11.6) | 1.01 (1.00–1.02) | 0.1717 | ||||
BMI | 27.6 (± 4.8) | 0.96 (0.92–0.99) | 0.0282 | 0.95 (0.91–0.99) | 0.0205 | ||
Charlson index | 4.6 (± 1.8) | 1.11 (1.02–1.22) | 0.019 | 1.18 (1.05–1.33) | 0.0067 | ||
ASA | I II III IV | 23 473 292 16 | 1.00 1.46 (0.53–5.10) 1.50 (0.54–5.30) 2.16(0.48–10.43) | – 0.5025 0.4760 0.4761 | |||
CEA | < 5 ≥ 5 | 596 182 | 1.00 1.57(1.08–2.2795) | – 0.0175 | 1.00 1.18 (0.76–1.81) | – 0.4442 | |
Tumor size | < 5 cm ≥ 5 cm | 516 246 | 1.00 0.81 (0.56–1.16) | – 0.2603 | |||
Location | Right colon Left colon | 382 422 | 1.00 0.60 (0.43–0.84) | – 0.0026 | 1.00 0.59 (0.40–0.87) | – 0.0076 | |
Technique | Laparoscopic Open | 559 242 | 1.00 0.92 (0.64–1.32) | – 0.6638 | |||
PO complications | AL Ileus Sepsis SSI Others | 45 (5.6%) 52 (6.5%) 20 (2.5%) 44 (5.5%) 90 (11.2%) | 1.18(0.57–2.27) 0.40(0.15–0.88) 0.16(0.01–0.80) 0.49(0.18–1.10) 0.98(0.57–1.61) | 0.6336 0.0385 0.0798 0.1124 0.9258 | 2.16(0.92–4.92) 0.26(0.07–0.70) 0.25(0.01–1.46) 0.84(0.28–2.23) 0.60(0.29–1.18) | 0.0692 0.0163 0.2039 0.7441 0.1544 | |
AJCC Stage | I IIA IIB/C III | 195 279 37 291 | 1.00 1.59(0.94–2.76) 3.59(1.56–8.04) 4.22(2.61–7.08) | – 0.087 0.0021 0 | 1.00 1.25(0.69–2.31) 2.17(0.73–6.14) 2.89(1.49–5.76) | – 0.475 0.1507 0.002 | |
T stage | T1 T2 T3 T4 | 92 152 486 74 | 1.00 1.03(0.50–2.21) 2.13(1.18–4.12) 3.92(1.88–8.51) | – 0.9409 0.0172 0.0004 | |||
N stage | N0 N1 N2 | 508 12 84 | 1.00 2.33(1.60–3.40) 5.80(3.56–9.50) | – 0 0 | |||
Differentiation | G1 G2 G3 | 591 78 130 | 1.00 0.96(0.53–1.66) 1.42(0.92–2.16) | – 0.8877 0.1037 | |||
Vascular invasion | Yes No | 138 665 | 1.00 0.51(0.35–0.77) | – 0.001 | 1.00 0.99 (0.60–1.66) | – 0.9804 | |
Perineural invasion | Yes No | 110 692 | 1.00 0.36(0.24–0.55) | – 0 | 1.00 0.44 (0.26–0.75) | – 0.0023 | |
Intratumoral lymphocytes | No Mild Moderate Severe | 314 380 53 33 | 1.00 1.22(0.86–1.75) 2.19(1.17–4.04) 0.65(0.21–1.60) | – 0.2659 0.0126 0.3864 | |||
MSI | Yes No | 195 245 | 1.00 0.25(0.16–0.39) | – 0 | |||
Adjuvant therapy | Yes No | 307 494 | 1.00 0.49(0.36–0.69) | 0 | 1.00 0.80(0.47–1.35) | – 0.3966 | |
NLR | 3.2 (± 2.9) | 1.88(1.35–2.62) | 0.0002 | 1.60(1.08–2.37) | 0.018 | ||
LMR | 3.5 (± 1.9) | 0.49(0.34–0.69) | 0.0001 | 0.51(0.34–0.77) | 0.0013 | ||
PLR | 176.2 (± 107.8) | 1.74(1.25–2.43) | 0.0012 | 1.56(1.06–2.32) | 0.0252 | ||
