Table 1 The table presents a list of 15 upregulated and 9 downregulated genes, identified as significant in HNSC and ranked within the top 100 upregulated and downregulated genes. The upregulated genes MMP1, MMP10, IL24, MMP13 and downregulated genes PIP, TFF3, CRISP3 had the highest log2 fold change, the upregulated genes MMP1, IL24, ADAM12, MMP10 and downregulated genes ADH1B, FAM3B, KRT4 had the highest AUC values, and the upregulated genes MMP1, ISG15, MMP3, MMP13 and downregulated genes KRT4, PIP, PIGR showed the highest RPKM levels (highlighted in bold).
| Â | Â | Name | Log2 fold change | FDR p-value | ROC curve value | Avg. Tumor RPKM | Avg. Normal RPKM |
|---|---|---|---|---|---|---|---|
Upregulated genes significant in HNSC | 1 | MMP1 | 7.904 | 0 | 1 | 520.547 | 1.795 |
2 | MMP10 | 7.254 | 0 | 0.996 | 64.527 | 0.362 | |
3 | IL24 | 6.694 | 0 | 1 | 18.206 | 0.151 | |
4 | MMP13 | 6.676 | 0 | 0.978 | 74.946 | 0.647 | |
5 | IL11 | 6.163 | 0 | 0.964 | 3.952 | 0.039 | |
6 | CSAG3 | 5.758 | 0 | 0.895 | 2.353 | 0.029 | |
7 | MMP3 | 5.567 | 0 | 0.969 | 181.501 | 3.319 | |
8 | ISG15 | 5.548 | 0 | 0.976 | 259.293 | 5.170 | |
9 | CA9 | 5.385 | 0 | 0.849 | 2.328 | 0.049 | |
10 | MMP12 | 5.210 | 0 | 0.976 | 71.452 | 1.661 | |
11 | DNAH17 | 5.043 | 0 | 0.987 | 2.084 | 0.057 | |
12 | ADAM12 | 4.900 | 0 | 1 | 8.897 | 0.255 | |
13 | CXCL11 | 4.561 | 0 | 0.907 | 37.445 | 1.234 | |
14 | S100A7A | 4.455 | 0 | 0.965 | 23.727 | 1.067 | |
15 | KHDC1L | 4.426 | 0 | 0.978 | 3.978 | 0.162 | |
Downregulated genes significant in HNSC | 1 | PIP | -10.546 | 0 | 0.7 | 1.301 | 1426.734 |
2 | TFF3 | -8.626 | 0 | 0.86 | 0.381 | 131.549 | |
3 | CRISP3 | -8.597 | 0 | 0.887 | 1.430 | 504.455 | |
4 | SCGB3A1 | -7.991 | 0 | 0.342 | 0.224 | 52.109 | |
5 | PPP1R1B | -7.888 | 0 | 0.95 | 0.054 | 11.291 | |
6 | ADH1B | -7.687 | 0 | 0.983 | 0.099 | 18.877 | |
7 | PIGR | -7.395 | 0 | 0.648 | 4.396 | 543.606 | |
8 | KRT4 | -7.326 | 0 | 0.965 | 31.518 | 5263.881 | |
9 | FAM3B | -6.505 | 0 | 0.977 | 0.164 | 13.387 |
