Fig. 1 | Scientific Reports

Fig. 1

From: Cyclophilin D suppresses colorectal cancer progression through the activation of an autophagy-mediated apoptotic pathway

Fig. 1

Reduced CypD expression in CRC tumors and cell lines. (a) Differences in CypD protein expression between T1 and T4 CRC patients from the TCGA database (Mann-Whitney U test). (b) ROC curve analysis demonstrating CypD’s diagnostic performance for CRC. (c) Ppif gene expression in cancerous and para-carcinoma tissues of 11 CRC patients detected by RT-qPCR (paired t-test). (d) CypD protein levels in cancerous and para-carcinoma tissues of two additional CRC patients assessed by IF staining (scale bar = 20 μm; independent-samples t-test). (e) Comparison of CypD expression in human normal colorectal epithelial cells (NCM460) and three CRC cell lines (DLD-1, RKO, HCT116) by Western blotting (one-way ANOVA followed by Tukey’s HSD test). All Western blots were derived from physically cut membrane strips, and lanes non-adjacent or from different gels were separated by white space. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001.

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