Fig. 1 | Scientific Reports

Fig. 1

From: Cyclophilin D suppresses colorectal cancer progression through the activation of an autophagy-mediated apoptotic pathway

Fig. 1The alternative text for this image may have been generated using AI.

Reduced CypD expression in CRC tumors and cell lines. (a) Differences in CypD protein expression between T1 and T4 CRC patients from the TCGA database (Mann-Whitney U test). (b) ROC curve analysis demonstrating CypD’s diagnostic performance for CRC. (c) Ppif gene expression in cancerous and para-carcinoma tissues of 11 CRC patients detected by RT-qPCR (paired t-test). (d) CypD protein levels in cancerous and para-carcinoma tissues of two additional CRC patients assessed by IF staining (scale bar = 20 μm; independent-samples t-test). (e) Comparison of CypD expression in human normal colorectal epithelial cells (NCM460) and three CRC cell lines (DLD-1, RKO, HCT116) by Western blotting (one-way ANOVA followed by Tukey’s HSD test). All Western blots were derived from physically cut membrane strips, and lanes non-adjacent or from different gels were separated by white space. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001.

Back to article page