Fig. 1
An exploratory analysis of the UNOS dataset reveals distinct indication-drive groupings and time-associated trends. (A). Histogram of the number of lung transplants by year since 1987 split by restrictive indication (red). The timeline schematic below the x axis indicates how many observations were included for modeling for each model across various time frames. (B). Hexbin plots showing from top to bottom the relationship of ischemic time (hours), recipient age, and FEV1% at the time of transplant with sorted transplant date. Black dots on the ischemic time plot indicate the yearly median of ischemic time. P values and R-squared values were derived from linear regression on all three variables vs transplant year. (C). Principal components contour plots split by single and bilateral transplants, indicated in red. (D). Principal components contour plots split by indication (red). (E). Principal components scatterplot colored by transplant year with reference contour plot on the right. Early to most recent transplant years are illustrated from dark to light respectively.
