Fig. 2

(a) Volcano plot for contrasts of protein expression using the longitudinal approach with contrast 1: expression profile regarding operation effect on non-POD patients. Significantly regulated proteins (p < 0.05) are shown in red. Fold change (FC) threshold: 1.1, p-value is displayed in -log10(p), FC in log2(FC). (b) Volcano plot for contrasts of protein expression using the longitudinal approach with contrast 2: expression profile regarding operation effect on POD patients. Significantly regulated proteins (p < 0.05) are shown in red. Fold change (FC) threshold: 1.1, p-value is displayed in -log10(p), FC in log2(FC). (c) Volcano plot for contrasts of protein expression using the longitudinal approach with contrast 3: expression profile regarding interaction between operation and POD (pure POD effect). Significantly regulated proteins (p < 0.05) are shown in red. Fold change (FC) threshold: 1.1, p-value is displayed in -log10(p), FC in log2(FC).