Table 5 Repeated dose anti-inflammatory effect of Naproxen analogues.

From: Microwave synthesis of new naproxen analogues for chronic inflammation and their gastro-protective effect in post-operative model

Days

Ketoprofen

Naproxen

NS9 30 mg

NS10 30 mg

NS11 30 mg

NS12 30 mg

Vehicle

1

8.65 ± 0.52***

7.82 ± 0.35***

5.700 ± 0.35***

6.50 ± 0.40***

7.32 ± 0.35***

7.55 ± 0.44***

0.290 ± 0.05

2

8.45 ± 0.37***

7.86 ± 0.28***

5.750 ± 0.27***

6.68 ± 0.35***

7.24 ± 0.41***

7.38 ± 0.43***

0.7800.09

3

9.34 ± 0.26***

7.62 ± 0.51***

5.89 ± 0.31***

6.58 ± 0.40***

7.49 ± 0.32***

7.67 ± 0.25***

0.640 ± 0.12

4

9.78 ± 0.40***

7.97 ± 0.41***

5.96 ± 0.37***

6.78 ± 0.32***

7.34 ± 0.38***

8.21 ± 0.24***

0.490 ± 0.17

5

9.50 ± 0.42***

8.59 ± 0.22***

6.20 ± 0.40***

7.32 ± 0.34***

7.66 ± 0.35***

8.820 ± 0.41***

0.710 ± 0.07

6

10.31 ± 0.31***

9.12 ± 0.37***

7.21 ± 0.42***

8.25 ± 0.0.34***

8.48 ± 0.35***

9.75 ± 0.22***

0.810 ± 0.03

7

10.16 ± 0.42***

10.15 ± 0.40***

7.65 ± 0.31***

8.67 ± 0.34***

9.27 ± 0.28***

10.24 ± 0.34***

0.640 ± 0.11

  1. Data are expressed as mean ± SE of five for each group, N = 5, *P < 0.05, **P < 0.01, ***P < 0.001 significant compared with control. Statistical analysis was performed by Two-way ANNOVA with Bonferroni post hoc tests for multiple comparison.
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