Fig. 8
Comparison of epigenetic ages in NAT and tumor tissues of CRC patients using different aging and mitotic clocks. (a) Horvath multi-tissue clock; (b) Hannum clock; (c) PhenoAge; (d) GrimAge; (e) tnsc from epiTOC2; (f) tnsc2 from epiTOC2; (g) pcgtAge from epiTOC; (h) hypoSC (Hypo score) from Hypo clock. Red symbols indicate OMPs. tnsc: the estimated cumulative number of stem-cell divisions per stem-cell per year and per sample using the full epiTOC2 model; tnsc2: the estimated cumulative number of stem-cell divisions per stem-cell per year and per sample using an approximation of epiTOC2 which assumes all epiTOC2 CpGs have beta-values exactly 0 in the fetal stage; pcgtAge: this is the mitotic-score obtained using epiTOC model; hyposc: HypoScore by taking the average methylation of 678-solo-WCGWs which exhibit uniformly high methylation across fetal tissue types.
