Fig. 3 | Scientific Reports

Fig. 3

From: Low-density lipoprotein cholesterol drives multinucleated giant cell formation in response to mycobacterium bovis Bacille Calmette-Guérin

Fig. 3

A Quantification of N° of MGC per cm2 of culture plate after indicated time of culture without stimulation. BMDM from either wt or Ldlr-/- mice. Serial t-test. B: Quantification of N° of MGC per cm2 of culture plate after indicated time of culture stimulated with 106 particles heat-fixed BCG/ml. BMDM from either wt or Ldlr-/- mice. Serial t-test. C: Quantification of N° of MGC per cm2 of culture plate after indicated time of culture stimulated with 106 particles heat-fixed BCG/ml. cMoP from either wt or Ldlr-/- mice. Serial t-test. D: Quantification of N° of MGC per cm2 of culture plate after indicated time of culture stimulated with 106 particles heat-fixed BCG/ml and supplemented with or without 50 µg/ml LDL. BMDM from wt mice. Serial t-test. BMDM: Bone marrow-derived macrophages; BCG: Bacille Calmette-Guérin; MGC: Multinucleated giant cell; FBS: Fetal bovine serum; LDL: Low-density lipoprotein. cMoP: common monocyte progenitor.

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