Fig. 1
From: Single-cell analysis of B cell dysregulation in pediatric sepsis stratified by disease severity
Major circulating leukocyte populations in pediatric sepsis. a. Schematic overview of the study design, including participants with severe sepsis (n = 3), mild sepsis (n = 3), and healthy controls (HC, n = 4). b. Uniform Manifold Approximation and Projection (UMAP) visualization of major circulating leukocyte subsets with annotated cell type identities. c. Boxplots illustrating the relative abundance of each leukocyte population across the three study groups. d. Scatter plots showing differentially expressed genes (DEGs) between severe and mild sepsis (highlighted in red and blue, respectively) within each major cell type. e. Receiver Operating Characteristic (ROC) curve analysis displaying the area under the curve (AUC) scores for each leukocyte population, assessing their predictive performance in distinguishing severe from mild sepsis.
