Fig. 5
From: Single-cell analysis of B cell dysregulation in pediatric sepsis stratified by disease severity
The reduction of MHC IIlownaïve B cells in severe pediatric sepsis may be driven by increased extrinsic apoptosis and cellular migration. a. UMAP visualization of MHC IIlownaïve B cells across the three study conditions, annotated by subpopulation. b. Bar plots showing differences in the relative abundance of MHC IIlow naïve B cell subclusters across study groups. c. Heatmap of differentially expressed genes (DEGs) across MHC IIlownaïve B cell subclusters. d. Gene Ontology (GO) enrichment analysis of biological processes associated with DEGs identified in (c). e–f. Gene-pathway network analysis of DEGs in severe sepsis versus healthy controls for (e) CD20⁺ naïve B cells and (f) CD34⁺ naïve B cells.
