Fig. 3
Changes in migratory capacity of ASPC1, SW1990, and PANC1 cell lines prompted by MRTX1133 treatment. (A) Representative images of scratch assay experiments taken at 0 h, 12 h, and 24 h during the experiment. Following a one-day-long pre-treatment with 100 nM MRTX1133, wound closure was investigated for 24 h under the same treatment concentration while images were captured every hour. (B) Normalized data of scratch assay showing significantly slower wound closure in all the investigated cell lines upon treatment (**p ≤ 0.01). (C) Results of Boyden chamber experiments. Following a one-day-long pre-treatment with 100 nM MRTX1133, migration in Boyden chamber for 4 h under the same treatment concentration was measured. MRTX1133 significantly inhibited migratory activity of SW1990 and PANC1 (* ≤ p0.05). C: control samples, M: MRTX1133 treated specimens.
