Fig. 5 | Scientific Reports

Fig. 5

From: Loss of the liver circadian clock affects the expression of intrarenal renin-angiotensin system components

Fig. 5

Effect of targeted deletion of hepatic circadian clock genes on blood pressure and peptide hormone accumulation at ZT8. (a) systolic and (b) diastolic blood pressure of LCre, LBmal1, and LPer1/2 mice. (c) concentration of AGT in plasma, (d) Ang I, (e) Ang II, (f) Ang III, (g) Ang IV. (h) renin activity compared to standard. AGT: angiotensinogen; Ang: angiotensin. Data are presented as mean ± SEM (n = 6). One-way ANOVA with Dunnett’s post hoc test compared to LCre, ns: non-significant; * p < 0.05; ** p < 0.01; *** p < 0.001.

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