Fig. 6
Model. Comparison of two different tissues in two different mouse strains. In wild type mice (yellow box), liver and kidney have a functional circadian oscillator: Per1 and Per2 expression peak in the light phase (magenta), while Bmal1 expression peaks in the dark phase (green). The systemic RAAS (orange) and intrarenal RAS (blue) components are synchronized and peak during the dark phase. In liver-specific knock-out mice (light blue box) there is no functional oscillator in the liver, while the circadian oscillator in the kidney remains unaffected. Surprisingly, the systemic RAAS and the intrarenal RAS components are still partially synchronized albeit their peak is shifted towards the light phase.
