Fig. 1 | Scientific Reports

Fig. 1

From: Anti-PD-1 immune checkpoint inhibitor-induced cardiotoxicity is associated with dysfunctional metabolism, muscle wasting and autophagy

Fig. 1

Tumor characteristics of control and ICI-treated tumor bearing mice (Fig. 1a, b), and body mass and heart mass of control and ICI-treated mice (Fig. 1c-e). Relative tumor mass (a) was calculated by normalizing wet tumor mass in grams to body mass in grams. Estimated tumor volume (b) was calculated by using the following formula: tumor volume (mm3) = (a * b)2/2, with a being the longest diameter and b being the shortest diameter of the tumor. Body mass (c) was weighed in grams at baseline and endpoint. Absolute heart mass (d) was weighed in grams and then normalized to body mass in grams (e). CON + T, control tumor bearing group (n = 5); ICI + T, ICI treated tumor bearing group (n = 4 in Fig. 1A excluding one animal due to difficulties during tumor excision, n = 5 in Fig. 1B); N = 9/10. CON, control group (n = 5); ICI, ICI treated group (n = 5); N = 10. Values are reported as mean ± SD. *Significant difference, P < 0.05; **Significant difference, P < 0.01.

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