Fig. 6
Effect of antineoplastic drugs on inflammatory cytokines levels evaluated in serum of rat treated with PTX. Box plots showing the fold change in levels of selected cytokines after treatment with PTX and OHP. After 2 weeks a significant increase of IL-6 and GRO/KC(CXCL1) levels were observed in the serum of PTX-treated rats. Data are expressed as median and quartile values as well as maximum and minimum values. n = 7 for each experimental group *p < 0.05 or **p < 0.01 as compared to VEHPTX, using a nonparametric Mann–Whitney test. VEHPTX / VEHOHP, vehicle of PTX or OHP; PTX, paclitaxel; OHP, oxaliplatin.
