Fig. 1

In-vitro characterization of the prepared ROS-GLY. Optimized ROS-GLY batch exhibited a mean particle size of 1049.83 ± 11.2 nm (A). The zeta potential of the prepared optimized ROS-GLY vesicles was measured at 0.7 mV (B). The scanning electron microscopy images revealed that ROS-GLY is nearly spherical with a smooth surface (C). In-vitro drug release studies revealed that the prepared ROS-GLY batches achieved a cumulative drug release of 97.32 ± 6.19% over 24 hours, in contrast to the slow release of free drug within 24 hours of 54.6 ± 1.42% (D).