Fig. 1 | Scientific Reports

Fig. 1

From: High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma

Fig. 1

High Ano1 expression in the absence of high cyclin D1 is associated with poor prognosis in HPV-negative HNSCC. (A, B) Patients (HPV- negative cases from the TCGA HNSCC PanCancer Atlas dataset; n = 415) were classified in four groups based on the expression levels of Ano1 and Cyclin D1. (A) Correlation between Cyclin D1 and Ano1 mRNA expression levels; (B) Kaplan Meier curves and Cox regression hazard ratios (+/- 95% confidence intervals) for overall survival according to Ano1 and Cyclin D1 expression levels; (C) Kaplan Meier curves of overall survival for locally advanced HNSCC patients treated with CDDP-based RCTx (Charité cohort, n = 34) according to Ano1 and Cyclin D1 expression levels are shown.

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