Fig. 2 | Scientific Reports

Fig. 2

From: High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma

Fig. 2

Proteome analysis revealed common and unique protein expression changes uponCCND1orANO1silencing. (A, B) Volcano plots of fold changes upon CCND1(A) or ANO1(B) KD compared to LeGo, with significant upregulated proteins in red and downregulated proteins in blue; (C, D) Venn diagrams illustrating the number of common and unique proteins that were down- (C) or up-regulated (D) upon KD; (E-G) Pathway enrichment analysis referred to the Reactome dataset based on uniquely down- (blue) and upregulated proteins (red) upon CCND1 KD (E) and ANO1 KD (F), or common for both KD (G). Only the significant pathways (FDR < 0.05) are shown; (H) VEGF detection by ELISA upon CCND1 KD. Bars represent ± SEM from at least three independent experiments.

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