Fig. 4

ANO1 silencing resensitizes cells to DNA damaging treatment (radiation and CDDP). (A,B) Dose response curves to CDDP treatment (A) and radiation (B) in parental cells (upper) and after gene silencing (lower panels). Bars represent ± SEM from at least three independent experiments; (C) Classification of cells according to their sensitivity to radiation based on their D0. Symbols for cell lines correspond to those in B; (D) Correlation between Ano1 mRNA expression and radiosensitivity (D0).