Table 2 AI prediction of CHD overall. Maternal saliva metabolomics, clinical and demographic markers- Cross Validation approach (all CHD versus Controls) - Test Group (25 metabolite only model).

From: Precision fetal cardiology detects cyanotic congenital heart disease using maternal saliva metabolome and artificial intelligence

 

SVM

GLM

PAM

RF

LDA

DL

Ensemble

AUC

95% CI

0.8311

(0.6000-1)

0.8275

(0.6000-1)

0.8240

(0.6000-1)

0.8399

(0.6000-1)

0.8122

(0.6000-1)

0.8411

(0.6300-1)

0.8488

(0.6350-1)

Sensitivity

0.9050

0.9150

0.9000

0.9000

0.9050

0.9200

0.9250

Specificity

0.8700

0.8600

0.8750

0.8800

0.8680

0.9100

0.9100

  1. SVM: C9, Trp, Suc, DG(21:0_22:6), C16:2-OH, PEA, Glu, Ile, Spermidine, DG(18:0_20:4), -Met-His, alpha-AAA, C16-OH, DG(14:0_14:0), C14:2, OH-GlutAcid, Cer(d18:2/23:0), TMAO, 5-AVA, C8, Spermine, Cer(d18:1/18:1), DG(17:0_17:1), Trigonelline, C0.
  2. GLM: GUDCA, Lac, CE(18:1), Arg, Cit, AconAcid, Cer(d18:0/24:0), Val, Asp, Orn, FA(12:0), Cer(d18:1/26:0), Sarcosine, Gln, HipAcid, 3-Met-His, alpha-AAA, C16-OH, DG(14:0_14:0), C14:2, OH-GlutAcid, Gly, C12, CE(18:3), Tyr, FA(14:0), GCDCA.
  3. PAM: Gly, C12, CE(18:3), Tyr, FA(14:0), GCDCA, C6 (C4:1-DC), CE(16:0), CA, Cer(d18:1/24:0), Cer(d18:1/23:0), Cer(d18:0/18:0(OH)), Creatinine, DG(18:1_20:1), Cer(d18:1/20:0), p-Cresol-SO4, DG(17:0_18:1), EPA, DG(18:2_18:2), Phe, HArg, Cer(d18:2/14:0), SDMA, DG(18:1_18:4), Met.
  4. RF: Spermine, Cer(d18:1/18:1), DG(17:0_17:1), Trigonelline, C0, PAG, DG(18:2_18:4), C16, GLCA, DG(14:0_20:0), C10:2, CE(20:1), Cys, CE(22:2), Cer(d18:1/18:0), Histamine, C14:2-OH, Cer(d16:1/20:0), C18:1, C7-DC, CE(22:5), DG(16:1_18:1), DG(18:2_20:0), DCA, Cer(d18:0/20:0).
  5. LDA: DG(18:1_20:1), Cer(d18:1/20:0), p-Cresol-SO4, DG(17:0_18:1), EPA, DG(18:2_18:2), Phe, HArg, Cer(d18:2/14:0), SDMA, DG(18:1_18:4), Cer(d18:0/22:0), C9, Trp, Suc, DG(21:0_22:6), C16:2-OH, PEA, Glu, Ile, Spermidine, Cys, CE(22:2), Cer(d18:1/18:0), Histamine, C14:2-OH.
  6. DL: Leu, Cer(d18:2/24:1), DG(16:0_18:2), DG(18:1_20:2), DG-O(14:0_18:2), AABA, GABA, Cer(d18:0/24:1), GLCAS, FA(18:1), Cer(d16:1/22:0), Cer(d18:1/26:0), Sarcosine, Gln, HipAcid, 3-Met-His, alpha-AAA, C16-OH, DG(14:0_14:0), C14:2, OH-GlutAcid, Cer(d18:2/23:0), TMAO, 5-AVA, C8.
  7. Ensemble: GUDCA, Lac, CE(18:1), Arg, Cit, AconAcid, Cer(d18:0/24:0), Val, Asp, Orn, FA(12:0), CE(18:2), Cer(d18:1/26:1), Cer(d18:1/16:0), Cer(d18:0/22:0), C9, Trp, Suc, DG(21:0_22:6), C16:2-OH, PEA, Glu, Ile, Spermidine, DG(18:0_20:4).
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