Fig. 5 | Scientific Reports

Fig. 5

From: MiR-556-3p mediated repression of klotho under oxidative stress promotes fibrosis of renal tubular epithelial cells

Fig. 5

ROS activates Nrf2 to upregulate the expression of miR-556. (A) Nrf2 levels in the cytosol and nucleus fraction of HK-2 cells stimulated with vehicle control or H2O2. (B) Klotho and miR-556 expression in HK-2 cells with shCTRL or shNrf2. (C) Klotho and fibrotic gene expression in HK-2 cells with shCTRL or shNrf2. (D) Klotho and miR-556 expression in HK-2 cells with control or Nrf2 inhibitor ML385. (E) Klotho and fibrotic gene expression in HK-2 cells with shCTRL or shNrf2. *p < 0.1, **p < 0.01, ***p < 0.001.

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