Fig. 1

Comparative analysis of miRNA expression levels between SJS/TEN with SOC patients and healthy controls. This figure displays the quantitative miRNA PCR analysis results for specific miRNAs (let-7a-5p, let-7d-3p, let-7e-5p, miR-151a-3p, miR-151a-5p, miR-146a-5p, miR-130a-3p and miR-27b-3p) in plasma samples from two distinct groups: SJS: SJS/TEN with SOC patients, control: healthy controls. Quantification was performed using miR-39 as an internal control to normalize the data. The Y-axis indicates the fold increase in specific miRNA expression levels over the control samples. Data points represent the mean ± standard error of the mean (SEM) for patients with SJS/TEN with SOC in the chronic stage (n = 100) compared to the healthy controls (n = 92). Statistical significance between the groups is denoted by asterisks: *p < 0.001, **p < 0.0001, and ***p < 0.00001, suggesting significant upregulation of miRNAs in the SJS/TEN with SOC patient group relative to the controls.

SJS/TEN with SOC: Stevens-Johnson syndrome/Toxic Epidermal Necrolysis with Severe Ocular Complications.