Fig. 5 | Scientific Reports

Fig. 5

From: Investigating lung cancer microenvironment from cell segmentation of pathological image and its application in prognostic stratification

Fig. 5

Unraveling the biological mechanisms of LUAD disease linked to cellular activity via differentially expressed gene analysis. (a) Volcano plot depicting lymphocyte-related differential expression analysis via DESeq2. (b) Volcano plot depicting lymphocyte-related differential expression analysis via edgeR. (c) Common genes identified in lymphocytes through two differential gene expression analysis methods. (d) Heatmap constructed using the median lymphocyte content as a threshold. (e) Volcano plot depicting neutrophil-related differential expression analysis via DESeq2. (f) Volcano plot depicting neutrophil-related differential expression analysis via edgeR. (g) Common genes identified in neutrophils through two differential gene expression analysis methods. (h) Heatmap constructed using the median neutrophil content as a threshold. (i) COX regression analysis. (j) Survival curve based on the risk score calculated from neutrophil-focused COX regression analysis.

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