Table 2 Drug release study of Methotrexate (MTX) from B1, S1, and S3 composite beads.
From: An In Vitro Study of the Effects of Methotrexate Loaded Biocomposite Beads on MG63 Osteoblast Cells
Samples ID | ug/ml | Toxicity % | Viability % | ± SD | P- value | IC50 ± SD |
|---|---|---|---|---|---|---|
B1 | 1000 | 96.60 | 3.39 | 0.29 | 7.40E-10 | 306.99 ± 2.72 |
500 | 88.80 | 11.20 | 0.96 | 6.72E-09 | ||
250 | 50.08 | 49.91 | 1.47 | 4.78E-07 | ||
125 | 0.04 | 99.95 | 3.78 | 0.37 | ||
62.5 | 0 | 100 | 0.97 | 0.45 | ||
31.25 | 0 | 100 | 1.67 | 0.41 | ||
S1 | 1000 | 96.43 | 3.57 | 0.28 | 2.08E-09 | 204.74 ± 4.55 |
500 | 89.95 | 10.05 | 0.15 | 8.04E-10 | ||
250 | 65.39 | 34.61 | 1.32 | 4.41E-08 | ||
125 | 23.15 | 76.85 | 0.72 | 8.60E-10 | ||
62.5 | 0.70 | 99.29 | 0.81 | 0.03 | ||
31.25 | 0.13 | 99.87 | 0.91 | 0.33 | ||
S3 | 1000 | 96.38 | 3.61 | 0.098 | 1.11E-09 | 116.16 ± 1.57 |
500 | 90.78 | 9.21 | 0.67 | 5.92E-09 | ||
250 | 82.23 | 17.77 | 0.94 | 2.51E-08 | ||
125 | 56.74 | 43.25 | 0.81 | 2.69E-11 | ||
62.5 | 4.19 | 95.81 | 1.28 | 0.004 | ||
31.25 | 0.04 | 99.95 | 1.24 | 0.44 |
