Fig. 1

Genetic and transcriptional alterations of tryptophan metabolism genes in colon cancer. (A) Frequency and type of mutations in tryptophan metabolism. (B) CNV mutations are widely found in the genes with tryptophan metabolism including gain or loss. (C) CNV alteration on chromosome of tryptophan metabolism from 1 to 22. (D) The mRNA expression levels of tryptophan metabolism genes in carcinoma and adjacent tissues in TCGA. CNV,Copy Number Variation.* p < 0.05, * p < 0.01 and *** p < 0.001.