Fig. 3 | Scientific Reports

Fig. 3

From: Integrated single cell and bulk RNA sequencing analyses reveal the impact of tryptophan metabolism on prognosis and immunotherapy in colon cancer

Fig. 3

Validation of the risk score model in the TCGA and GEO independent cohorts. (A) Kaplan–Meier curve of OS in TCGA high-risk and low-risk patients. (B) The time-dependent ROC curve for the TCGA risk score. (C) The high-risk group of patients in the TCGA cohort had a high risk score (D) Patients in the high-grade group in the TCGA had lower survival days. (E) PCA showed that the TCGA high-risk and low-risk groups had identifiable dimensions. F 3dPCA showed that the TCGA high-risk group and the low-risk group can be well distinguished. (G) Kaplan–Meier curve of OS in GEO high-risk and low-risk patients. (H) The time-dependent ROC curve for the GEO risk score. (I) The high-risk group of patients in the TCGA cohort had a high risk score (J) Patients in the high-grade group in the TCGA had lower survival days. (K) PCA showed that the GEO high-risk and low-risk groups had identifiable dimensions (L) 3dPCA showed that the GEO high-risk group and the low-risk group can be well distinguished. OS, Overall Survival; TCGA, The Cancer Genome Atlas; ROC,Receiver Operating Characteristic Curve; PCA,Principal Component Analysis; 3dPCA,3d Principal Component Analysis; GEO,Gene Expression Omnibus.

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