Fig. 3 | Scientific Reports

Fig. 3

From: Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate

Fig. 3

Conditional and joint analysis of TWAS-significant loci on chromosomes 17 and 8 associated with hyperaldosteronism. (a) Conditional and joint analysis of the TWAS-significant locus on chromosome 17. (b) Conditional and joint analysis of the TWAS-significant locus on chromosome 8. In both panels, the top section shows all genes within each locus (gray), with marginally significant TWAS-associated genes highlighted in blue and jointly significant genes highlighted in green. The bottom section presents Manhattan plots of GWAS summary statistics: gray points represent the original GWAS data, while blue points indicate results after conditioning on the jointly significant genes (green). The x-axis denotes genomic coordinates, and the y-axis represents -log10(p-values) of GWAS associations.

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