Fig. 4 | Scientific Reports

Fig. 4

From: Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate

Fig. 4

Notable SMR results for the association between TWAS-significant genes and hyperaldosteronism risk. The analysis includes data from GTEx (whole blood and adrenal gland) and the eQTLGen Consortium. Each row lists a gene, its source data, and its odds ratio (OR) with 95% confidence interval (CI) for hyperaldosteronism risk. In the forest plots, OR values greater than 1 indicate an increased risk, while values below 1 suggest a protective effect. Genes are highlighted in color-coded rows to differentiate individual genes and enhance readability. The FDR_P_SMR column presents false discovery rate (FDR)-adjusted p-values for SMR significance, and the P_HEIDI column provides heterogeneity statistics to assess the robustness of each association.

Back to article page