Table 1 Characteristics of study participants.

Baseline characteristics	DAPT (n = 31)		P
Age (years) (mean (SD))	66 (56–76)	65 (54–73)	0.43
Sex (male)	18 (58.1)	23 (74.2)	0.18
Current smoking^#	9 (29.0)	12 (38.7)	0.42
Current drinking^#	5 (16.1)	7 (22.6)	0.52
Medical history
Hypertension	26 (83.9)	19 (61.3)	0.04
Diabetes	9 (29.0)	12 (38.7)	0.42
Atrial fibrillation	2 (6.5)	4 (12.9)	0.39
Time from onset of symptoms to receipt of assigned treatment, median (IQR), h	1.5 (1.0–3.5)	2.0 (1.0–2.5)	0.66
INR at treatment, median (IQR), s	1.01 (0.98–1.07)	0.97 (0.92–1.00)	0.01
Systolic blood pressure at treatment, median (IQR), mmHg	167 (144–193)	159 (128–189)	0.03
Diastolic blood at treatment, median (IQR), mmHg	95 (73–105)	86 (71–105)	0.72
Blood glucose level at treatment, median (IQR), mmol/L	7.07 (6.29–10.70)	8.58 (6.71–10.28)	0.30
NIHSS score at treatment, median (IQR)^$	1.0 (1.0–2.0)	4.0 (2.0–5.0)	0.01
Onset-to-needle (OTN), median (IQR), min%	NA	149.1 (98.0–179.0)
Door-to-needle (DTN), median (IQR), min^	NA	44.7 (36.0–45.0)
Presumed stroke cause*			0.46
Large artery atherosclerosis	9 (29)	11 (35.5)
Small artery occlusion	4 (13.0)	6 (19.4)
Cardioembolic	13 (41.9)	10 (32.3)
Others	5 (16.1)	4 (12.9)

^#Current smoking was consuming more than 1 cigarette per day within 1 year before the onset of the disease. Current drinking defined as consuming alcohol more than once a week within 1 year before the onset of the disease.
^$Patients with NIHSS ≤ 5 were eligible for this study; NIHSS scores range from 0 to 42, with higher scores indicating more severe neurological deficit.
NA not applicable.
^%Onset-to-needle, Time from onset of symptoms to needle.
^Door-to-needle, Time from patient arrival at hospital to treatment.
*The presumed stroke cause was classified according to the Trial of Org 10,172 in the Acute Stroke Treatment (TOAST) classification system. Others were including undetermined causes and other.

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