Table 3 Effect of motor and olfactory subtype interaction on estimated values: a GLM analysis adjusted for age, sex, and disease duration.

From: The added value of anosmic subtype on motor subtype in Parkinson’s disease: a pilot study

 

PIGD NA as reference

TDPD TA as reference

TDPD NA as reference

B

95% CI

p value

B

95% CI

p value

B

95% CI

p value

Total

PIGD TA

3.245

-5.80, 12.29

0.4790

11.234

2.32, 20.15

0.0139*

19.646

9.56, 29.73

0.0002*

PIGD NA

1.000

-

-

7.988

-1.89, 17.87

0.1122

16.400

5.73, 27.07

0.0029*

TDPD TA

-7.988

-17.87, 1.89

0.1122

1.000

-

-

8.412

-2.27, 19.09

0.1216

TDPD NA

-16.400

-27.07, -5.73

0.0029*

-8.412

-19.09, 2.27

0.1216

1.000

-

-

Part III

PIGD TA

2.187

-3.58, 7.95

0.4540

0.066

-5.62, 5.75

0.9816

6.297

-0.13, 12.72

0.0547

PIGD NA

1.000

-

-

-2.121

-8.42, 4.18

0.5063

4.110

-2.69, 10.91

0.2339

TDPD TA

2.121

-4.18, 8.42

0.5063

1.000

-

-

6.231

-0.58, 13.04

0.0724

TDPD NA

-4.110

-10.91, 2.69

0.2339

-6.231

-13.04, 0.58

0.0724

1.000

-

-

MoCA

PIGD TA

0.143

-1.93, 2.22

0.8918

0.826

-1.23, 2.88

0.4272

-1.777

-4.10, 0.54

0.1321

PIGD NA

1.000

-

-

0.683

-1.60, 2.96

0.5547

-1.920

-4.38, 0.54

0.1253

TDPD TA

-0.683

-2.96, 1.60

0.5547

1.000

-

-

-2.603

-5.07, -0.14

0.0387

TDPD NA

1.920

-0.54, 4.38

0.1253

2.603

0.14, 5.07

0.0387

1.000

-

-

PDQ-39 SI

PIGD TA

4.342

-3.20, 11.88

0.2567

12.942

5.50, 20.39

0.0008*

13.983

5.56, 22.40

0.0013*

PIGD NA

1.000

-

-

8.601

0.32, 16.88

0.0418

9.641

0.70, 18.58

0.0347

TDPD TA

-8.601

-16.88, -0.32

0.0418

1.000

-

-

1.041

-7.91, 9.99

0.8183

TDPD NA

-9.641

-18.58, -0.70

0.0347

-1.041

-9.99, 7.91

0.8183

1.000

-

-

  1. Table 3 presents clinical scores, including M-UPDRS total, M-UPDRS part III, MoCA, and PDQ-39 SI, adjusted for age, sex, and disease duration using the general linear model (GLM). The reference groups for comparison are listed in the first row: PIGD NA (left three columns), TDPD TA (middle three columns), and TDPD NA (right three columns). Higher scores indicate greater severity for all measures, except for MoCA, where higher scores indicate better cognitive function.
  2. B, beta coefficient; CI, confidence interval; GLM, general linear model; MoCA, Montreal Cognitive Assessment; M-UPDRS, Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale; NA, Non-anosmia; PDQ-39 SI, 39-item Parkinson’s Disease Questionnaire Summary index; PIGD, postural instability and gait disturbance; TA, total-anosmia; TDPD, Tremor-dominant Parkinson’s disease.
  3. * Two-tailed p < 0.0167, adjusted using the Bonferroni method.
  4. Two-tailed p < 0.0042, adjusted using the Bonferroni method to further account for comparisons across four clinical outcomes.
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