Fig. 7
From: 20-HETE mediates Ang II-induced cardiac hypertrophy via ROS and Ca2+ signaling in H9c2 cells
Inhibition of 20-HETE production or blockade of its action alleviates intracellular Ca2+ overload and NFAT3 activation induced by Ang II. (A) Representative immunofluorescence images of Fluo-4 AM (scale bar: 20 μm) and quantification of mean fluorescence intensity of intracellular Ca2+ concentrations in the different groups. *P < 0.05 vs. Control group, #P < 0.05 vs. Ang II or 20-HETE group, n = 4. (B–C) Relative protein expression levels of CaN, NFATc3 and NFATn3 in the indicated groups. *P < 0.05 vs. Control group, #P < 0.05 vs. Ang II or 20-HETE group, n = 3.
