Table 1 Baseline characteristics.
All patients | 2–5 years old | 6–11 years old | ≥ 12 years old | p-value | |
|---|---|---|---|---|---|
n | 49 | 15 | 14 | 20 | |
Number of boys (%) | 57 | 47 | 50 | 70 | 0.315 |
Age at diagnosis (months)* | 8.9 (3.4, 24.2) | 11.5 (3.6, 22.0) | 6.4 (1.8, 20.1) | 10.0 (4.7, 24.9) | 0.367 |
Age at the start of LUM/IVA (years)* | 9.3 (5.5, 14.2) | 4.6 (3.5, 5.2) | 8.5 (7.9, 9.5) | 16.2 (13.5, 17.2) | |
Sweat chloride (mmol/L)* | 74 (67, 86) | 70 (66, 78) | 73 (62, 77) | 83 (69, 92) | 0.154 |
ppFEV1 (%)* | 94 (79, 112) | – | 109 (103, 122) | 82 (70, 96) | 0.001 |
ppFVC (%)* | 103 (87, 118) | – | 112 (98, 122) | 93 (78, 110) | 0.037 |
Fecal elastase (µg/g) | 1.000 | ||||
< 100 | 39 (98%) | 13 (100%) | 12 (100%) | 14 (93%) | |
100–200 | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | |
> 200 | 1 (2%) | 0 (0%) | 0 (0%) | 1 (7%) | |
CFRD | 4/49 (8%) | 0/15 (0%) | 0/14 (0%) | 4/20 (20%) | 0.034 |
P. aeruginosa colonization | 0.276 | ||||
Never | 10 (21%) | 3 (20%) | 3 (21%) | 4 (21%) | |
Free | 19 (40%) | 4 (27%) | 6 (43%) | 9 (47%) | |
Intermittent | 14 (29%) | 8 (53%) | 3 (21%) | 3 (16%) | |
Chronic | 5 (10%) | 0 (0%) | 2 (14%) | 3 (16%) |
