Fig. 7

Single-cell analysis of pyrimidine metabolism and cell-cell interactions in prostate cancer. (A) UMAP plot showing the clustering of different cell types in AR + prostate cancer tissues, including cancer cells, basal cells, luminal epithelial cells, luminal cells, endothelial cells, and smooth muscle cells. (B) Bubble plot showing the expression of marker genes used for cell type annotation. (C) UMAP plot showing the expression of RRM2. (D) UMAP plot of AUC scores for the Regulation of Androgen Receptor Activity signaling pathway across different cell types. (E) UMAP plot of AUC scores for the Pyrimidine Metabolism pathway across different cell types. (F) Cell-cell interaction network illustrating the relationships between different cell types in prostate cancer tissues. (G) Bubble plot showing the metabolic activity levels in various cell types.